Difference Between Hemophilia A and B and C
Overview of Hemophilia A and B and C
The most significant distinction in Hemophilia A and B and C is the fact that hemophilia A can be attributed to a deficiency in the clotting factor VIII. Hemophilia B results from the lack of the clotting factor IX. hemophilia C results from the lack of clotting factor IX.
Hemophilia A and B is caused by an inheritable recessive X-linked condition that has an indefective gene on the X the chromosome. Males are born with only one X chromosome and females possess two the X the chromosomes. Males suffering from hemophilia is carrying one of the defective genes in the X chromosome.
Thus, the majority of patients suffering from hemophilia are men. Hemophilia C doesn’t follow any pattern that is X-linked since the mutation is located in a gene on chromosome 4. Thus, hemophilia C impacts the male and female in equal measure.
Hemophilia A (HBA) is an X-linked genetic bleeding disorder which results in blood clotting disorders and irregular bleeding patterns. Hemophilia A is caused by either deficient levels or absence of the factor VIII protein involved with creating blood clots forming, so more males suffer than females from Hemophilia A.
Signs and symptoms associated with Hemophilia A can vary in intensity depending upon its severity; they typically involve long-term bleeding following injuries, surgeries or dental work as well as sudden muscle and joint inflammation that leads to sudden bouts of bleeding. Patients diagnosed with this disorder might also find themselves more prone to excessive bleeding than normal and frequently develop deep bruises or hematomas.
Diagnostic of Hemophilia It often requires physical exam, medical history review and blood testing in order to ascertain which factors lead to blood clotting. Genetic tests may also be conducted either to verify a diagnosis or establish carrier status.
Hemophilia A is treated by administering intravenous infusions of concentrated clotting factors to replace what’s missing and manage bleeding episodes or as prophylactic therapy to avoid them altogether. Physical therapy or pain management techniques may be utilized as well to address muscle and joint injuries caused by episodes.
Hemophilia A is the most frequent form of Hemophilia and affects one out of every 5,000 to 10,000 males; unfortunately there is no known cure; however when treated and managed appropriately those living with Hemophilia A can lead relatively normal lives.
Hemophilia B is a genetic bleeding disorder affecting blood clotting. This condition results from either insufficient amounts or no presence of Clotting Factor IX protein that aids blood clot formation; commonly referred to as Christmas Disease in recognition of the first patient who was ever diagnosed.
Hemophilia B is also an X-linked recessive condition, meaning it affects more males than females. Like Hemophilia A, symptoms for Hemophilia B include prolonged bleeding from injuries or surgery as well as spontaneous joint and muscle bleeding; occasional spontaneous bouts may even develop spontaneously! In addition, those living with Hemophilia B can also easily bruise as well as developing deep bruises (hematomas or deep bruises).
Hemophilia B can be diagnosed similarly to Hemophilia A; diagnosis requires physical exam, medical history review and blood testing of clotting factors; genetic testing can also be utilized as part of diagnosis or carrier status determination.
Treatment for Hemophilia B involves administering intravenous infusions of clotting factor concentrate to replace missing clotting factors and control bleeding episodes, or as prophylactic measures against future bleeding events. Physical therapy or pain management may be utilized as well to address joint and muscle damage caused by bleeding episodes.
Hemophilia B is less frequent than Hemophilia A and typically affects one out of 25,000 to 30,000 males. While no cure exists, with proper management people with Hemophilia B can live relatively normal lives.
Hemophilia C is an uncommon bleeding disorder affecting blood clotting, caused by deficiency or absence of Clotting Factor XI – an essential protein required to form blood clots – unlike Hemophilia A and B which are autosomal recessive disorders and thus affect only males equally.
Hemophilia C symptoms vary in intensity but typically include mild to moderate bleeding from injuries or surgeries as well as spontaneous joint and muscle bleeding. People living with Hemophilia C often bruise easily and develop deep bruises; women may even experience heavy menstrual periods or postpartum hemorrhaging as a side effect of having this genetic disease.
Diagnosing Hemophilia C typically involves conducting a physical exam and reviewing one’s medical history, followed by blood tests measuring clotting factors and genetic testing to confirm or rule out carrier status.
Hemophilia C treatments are similar to Hemophilia A and B; intravenous infusion of clotting factor concentrate is used to replace missing clotting factors as needed or prophylactically to avoid bleeding episodes, and physical therapy and pain management may be utilized during episodes to manage joint and muscle damage caused by bleeding episodes.
Comparison of Hemophilia A, B, and C
Hemophilia A, B, and C are three conditions caused by deficiencies or absences of certain clotting factors; however, each has distinct features. Here are the major distinctions among them:
Hemophilia A is caused by an absence or deficiency of clotting factor VIII; Hemophilia B by one or both clotting factor IX and Hemophilia C by both.
Hemophilia A and B are both X-linked recessive disorders, meaning they tend to affect males more frequently than females and can be passed on from carrier mothers. On the other hand, Hemophilia C can affect both genders equally and requires two copies of its affected gene from both parents for inheritance.
Hemophilia A and B tend to be more severe than Hemophilia C; usually with Hemophilia A/B clotting factor levels becoming extremely low or absent altogether, while in Hemophilia C levels tend to only partially decline.
Hemophilia A is considered to be the more common type of Hemophilia and affects around one in 5,000 to 10,000 males. Hemophilia C and B are more rarely, with C being affecting one and 500,000 persons, respectively.
All three forms of Hemophilia require replacing missing clotting factors via intravenous infusion of a clotting factor concentrate, with frequency and dosage dependent upon severity of condition.
Hemophilia A, B, and C are genetic bleeding disorders caused by deficiencies or absences of certain clotting factors. This condition may lead to spontaneous joint and muscle bleeding as well as prolonged bleeding following injury, surgery or dental work. Hemophilia A and B are both X-linked recessive disorders that typically impact males more often than females; Hemophilia C however can impact both genders equally.
Treatment for all three forms involves infusing intravenous infusion of clotting factor concentrate to replace missing clotting factors; with proper management and care plans in place, people living with Hemophilia can lead relatively normal lives.