Fresh Frozen Plasma and Cryoprecipitate

Difference Between Fresh Frozen Plasma and Cryoprecipitate

Definition of Fresh Frozen Plasma and Cryoprecipitate

Fresh Frozen Plasma and Cryoprecipitate are both blood products used in transfusion medicine.

Fresh Frozen Plasma (FFP) refers to blood collected from donors that has been separated from red blood cells and frozen within 8 hours after collection at temperatures below -18degC (-0.4degF), in order to preserve all its essential clotting factors, plasma proteins, and components found within normal blood plasma – providing transfusion-grade solutions in cases where there may be severe hemorrhaging due to deficiencies or massive bleeding. It provides all these elements necessary for restoration of volume as well as providing various clotting factor deficiencies or massive bleeding situations.

Fresh Frozen Plasma
Figure-No-01: Fresh Frozen Plasma

Cryoprecipitate is a blood product derived from Fresh Frozen Plasma (FFP). To produce it, simply thaw FFP at an controlled temperature and collect any precipitate formed during its thawing process. Cryoprecipitate contains specific clotting factors including fibrinogen, von Willebrand factor factor VIII and factor XIII that are used in treating bleeding disorders caused by deficiencies or dysfunction of these factors – for instance: hemophilia, von Willebrand disease and fibrinogen disorders among others.

Differences between FFP and Cryoprecipitate

FFP (Fresh Frozen Plasma) and Cryoprecipitate are two different blood products that serve specific purposes in medical treatments.

FFP and Cryoprecipitate
Figure-No-02: FFP and Cryoprecipitate

Here are the key differences between FFP and Cryoprecipitate:

  1. Composition:
    • FFP: Fresh Frozen Plasma is the liquid portion of human blood that is separated from the red blood cells and platelets. Blood contains numerous components including clotting factors, albumin, immunoglobulins and other plasma proteins.
    • Cryoprecipitate: Cryoprecipitate is a concentrated form of specific clotting factors that precipitate out of FFP when it is thawed. It contains high levels of fibrinogen, von Willebrand factor, factor VIII, factor XIII, and fibronectin.
  2. Indications for use:
    • FFP: FFP is used primarily as a multifactor clotting factor replacement therapy in cases involving liver disease, disseminated intravascular coagulation (DIC), or massive transfusions.
    • Cryoprecipitate: Cryoprecipitate is commonly prescribed to address specific clotting factor deficiencies, including hemophilia A, von Willebrand disease or fibrinogen deficiencies.
  3. Preparation and storage:
    • FFP: Fresh Frozen Plasma is prepared by separating plasma from donated whole blood and freezing it within 8 hours of collection.Store it at temperatures no higher than -18degreeC for at least one year for optimal storage conditions.
    • Cryoprecipitate: Cryoprecipitate is derived from FFP by thawing the plasma at a controlled temperature and then separating the precipitated clotting factors. It is typically stored at -18°C or lower for up to one year.
  4. Clinical considerations:
    • FFP: FFP administration requires a larger volume compared to cryoprecipitate because it contains a broader range of clotting factors. It may also carry a higher risk of fluid overload due to the larger volume infused.
    • Cryoprecipitate: Cryoprecipitate is administered in a smaller volume compared to FFP since it is a concentrated form of specific clotting factors. This reduces the risk of fluid overload. However, it is essential to verify compatibility and screen for infectious diseases before transfusion.

Understanding the differences between FFP and Cryoprecipitate is crucial for healthcare professionals to ensure appropriate use and optimal patient care based on the specific indications and compositions of these blood products.

Similarities Between Fresh Frozen Plasma and Cryoprecipitate

  • The cryoprecipitate, which is fresh and frozen in nature, two blood components, are that are made by blood plasma.
  • Both of them are yellow in hue.
  • They are a source of fibrinogen.
  • It takes about 30 minutes to prepare the two blood components.
  • Both blood components have the same price.
  • Freezed plasma or cryoprecipitate could be utilized in the event of issues with blood, such as problems with the clotting process.

Comparison chart

Topic FFP Cryoprecipitate
Volume 250 to 300 mL 10 to 20 mL
Time to prepare 30 minutes 30 minutes
Fibrinogen 700 to 800 mg 150 to 250 mg
Other coagulation factors All, including factors II, VII, VIII, IX, X, XI, and vWF Factors VIII, XIII, and vWF


Fresh Frozen Plasma (FFP) and Cryoprecipitate are two distinct blood products with distinct compositions, indications for use, preparation methods, storage needs and storage requirements. FFP consists of the liquid portion of blood with various clotting factors in it which helps treat multiple deficiencies related to bleeding disorders or coagulation deficiencies; on the other hand, Cryoprecipitate is derived from FFP in concentrated form in order to treat deficiencies caused by hemophilia A or von Willebrand disease, or fibrinogen deficiencies in patients suffering these deficiencies or deficiencies.

Understanding the differences between FFP and Cryoprecipitate for medical professionals is vitally important, enabling them to make educated decisions regarding which blood product to prescribe based on a patient’s individual needs and characteristics, including indications, compositions and storage requirements – ultimately increasing safety while optimizing treatment results.